CONTROLLED DELIVERY OF ANTIRETROVIRAL DRUG-LOADED CROSS-LINKED MICROSPHERES BY IONIC GELATION METHOD

Formulation and evaluation of captropril microspheres by ionic gelation technique

The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered on the fact that the drug is freely water soluble. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive use as a drug of choice in the treatme...

Ionic Gelation Controlled Drug Delivery Systems for Gastric-Mucoadhesive Microcapsules of Captopril

A new oral drug delivery system was developed utilizing both the concepts of controlled release and mucoadhesiveness, in order to obtain a unique drug delivery system which could remain in stomach and control the drug release for longer period of time. Captopril microcapsules were prepared with a coat consisting of alginate and a mucoadhesive polymer such as hydroxy propyl methyl cellulose, car...

preparation of chitosan nanoparticles loaded by tramadol using ionic gelation method

Floating controlled drug delivery system of famotidine loaded hollow microspheres (microballoons) in the stomach.

Most of the floating systems have an inherent drawback of high variability in the GI transit time, invariably affecting the bioavailability of drug. An attempt has been made to develop floating drug delivery system for improving the drug bioavailability by prolongation of gastric residence time of famotidine in stomach. The floating microballoons were prepared using polymer Eudragit L-100 by so...

Preparation, evaluation and bioavailability studies of Indomethacin loaded PEA polymeric microspheres for controlled drug delivery

The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and thereby to maintain the desired drug concentrations during treatment. This idealized objective can be achieved by targeting the drugs to a specific organ or tissue with the help of controlling the release rate of the drug during the transit time in ...